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CVD

Description

The assay covers the following 12 mutations

FV G1691A (Leiden)
FV H1299R (R2)
Prothrombin G20210A
Factor XIII V34L
ß- Fibrinogen -455 G>A
PAI-1 4G/5G
HPA 1 ( a / b)
MTHFR C677T
MTHFR A1298C
ACE I/D
Apo B R3500Q
Apo E2/E3/E4

Intended Use

A number of genetic and environmental risk factors have been found or suspected to predispose to cardiovascular disease (CVD), the term collectively used for disorders of the heart and blood vessels. Among the environmental components associated with CVD are physical activity, diet, alcohol and drug consumption, smoking and stress. Genetic susceptibility may be caused by mutations and polymorphisms in a variety of genes mainly involved in blood coagulation, regulation of blood pressure, and metabolism of lipids, glucose, homocysteine or iron. Among the candidate markers for inherited CVD risk are variations in the genes for blood coagulation factors V (FV), II (prothrombin), and XIII (FXIII), ß-fibrinogen (FGB), platelet glycoprotein IIIa (GPIIIa), plasminogen activator inhibitor-1 (PAI-1), 5,10- methylenetetrahydrofolate reductase (MTHFR), angiotensin-converting enzyme (ACE), as well as apolipoproteins B (Apo B) and E (Apo E).



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Copyright © 2009 - 2019 İnvitrotek A.Ş. All Right Reserved by Invitrotek
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