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K-RAS

Description

The KRAS StripAssay covers 10 mutations Kodon 12 Ala, Arg, Asp, Cys, Ile, Leu, Ser, Val
Kodon 13 Asp, Cys

Kodon 12 Ala, Arg, Asp, Cys, Ile, Leu, Ser, Val
Kodon 13 Asp, Cys

Intended Use

The KRAS gene encodes the human cellular homolog of a transforming gene isolated from the Kirsten rat sarcoma virus. Like the other members of the ras gene family (HRAS, NRAS), the KRAS protein is a 21 kD GTPase and an early player in many signal transduction pathways. While wildtype KRAS plays a vital role in normal cellular signaling processes, including proliferation, differentiation and senescence, mutated forms of the gene are potent oncogenes that are found in many human cancers (e.g. colon cancer, pancreatic cancer, lung cancer, leukemias). The most critical region of the KRAS gene for oncogenic activation are mutations in codons 12 and 13, causing the protein to accumulate in the active GTP-bound state. KRAS mutations were shown to be also predictive for the response to cancer therapy with certain anti-EGFR monoclonal antibodies (panitumumab/Vectibix®, cetuximab/Erbitux®) and tyrosine kinase inhibitors (erlotinib/Tarceva®, gefitinib/Iressa®).



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