Description

The PGX-HIV StripAssay identifies five polymorphic loci: MDR1 3435 C>T, CYP2D6 1795delT (6), 1934 G>A (4), 2637delA (3), and CCR5 32bp deletion.

Intended Use

Highly active antiretroviral therapy (HAART), the combined use of different types of antiretroviral drugs, has brought substantial clinical, virological and immunological improvements to HIVinfected patients and has led to a large reduction in AIDS-related mortality in countries where it became available. However, HAART still fails in a considerable number of cases, and host factors have been shown to contribute to the observed differences in the response to treatment. Among the known factors associated with the success of HIV antiretroviral treatment are allelic variants of the multidrug transporter P-glycoprotein 1 (MDR1), the cytochrome P450 isozyme 2D6 (CYP2D6) and the C-C chemokine receptor 5 (CCR5).