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PGX-TPMT

Description

Genetic variants dedected:
TPMT alleles *1, *2, *3A, *3B and *3C.

Intended Use

Thiopurines are widely used in the treatment of leukemias and autoimmune disorders, and as immunosuppressants after organ transplantation. Thiopurine compounds are converted to therapeutically inactive metabolites by the enzyme thiopurine S-methyltransferase (TPMT) which exists in different isoforms. Some TPMT isoforms have substantially reduced enzyme activity which leads to accumulation of higher thiopurine concentrations when receiving standard dosage. Myelosuppression, a toxic effect on the bone marrow, may thus occur. Identification of a patient’s individual TPMT isoform is crucial for avoiding toxic effects of thiopurines.



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